Article

Active microrheology using pulsed optical tweezers to probe viscoelasticity of Lamin A towards diagnosis of laminopathies

2021-02-06

Abstract excerpt

Lamins are nucleoskeletal proteins of mammalian cells that stabilize the structure and maintain the rigidity of the nucleus. These type V intermediate filament proteins which are predominantly of A and B types provide necessary tensile strength to the nucleus. Single amino acid missense mutations occurring all over the lamin A protein form a cluster of human diseases termed as laminopathies, a few of which princip...

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Literature Corpus work: 72936f22-891a-56e7-bfd6-2c79d15cd34f
DOI: 10.1101/2021.02.05.429901

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