Human cardiac β-myosin powerstroke energetics: Thin filament, Pi displacement, and mutation effects.

Abstract excerpt

The powerstroke of human cardiac β-myosin is an important stage of the cross-bridge cycle that generates force for muscle contraction. However, the starting structure of this process has never been resolved, and the relative timing of the powerstroke and inorganic phosphate (Pi) release is still controversial. In this study, we generated an atomistic model of myosin on the thin filament and utilized metadynamics...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Models, Molecular
• Share to Molecular Dynamics Simulation
• Share to Mutation