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Article

Controlling load-dependent kinetics of β-cardiac myosin at the single-molecule level.

Nature structural & molecular biology - 1 Jun 2018

Liu Chao, Kawana Masataka, Song Dan, Ruppel Kathleen M, Spudich James A

Abstract excerpt

Concepts in molecular tension sensing in biology are growing and have their origins in studies of muscle contraction. In the heart muscle, a key parameter of contractility is the detachment rate of myosin from actin, which determines the time that myosin is bound to actin in a force-producing state and, importantly, depends on the load (force) against which myosin works. Here we measure the detachment rate of...

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Identifiers

PMID: 29867217
DOI: 10.1038/s41594-018-0069-x
PMCID: PMC6092189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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