Article
KIF1A is kinetically tuned to be a superengaging motor under hindering loads.
Proceedings of the National Academy of Sciences of the United States of America - 10 Jan 2023
Pyrpassopoulos Serapion, Gicking Allison M, Zaniewski Taylor M, Hancock William O, Ostap E Michael
Abstract excerpt
KIF1A is a highly processive vesicle transport motor in the kinesin-3 family. Mutations in KIF1A lead to neurodegenerative diseases including hereditary spastic paraplegia. We applied optical tweezers to study the ability of KIF1A to generate and sustain force against hindering loads. We used both the three-bead assay, where force is oriented parallel to the microtubule, and the traditional single-bead assay,...
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