Article

KIF1A is kinetically tuned to be a super-engaging motor under hindering loads

2022-05-30

Abstract excerpt

KIF1A is a highly processive vesicle transport motor in the kinesin-3 family. Mutations in KIF1A lead to neurodegenerative diseases including hereditary spastic paraplegia. We applied optical tweezers to study the ability of KIF1A to generate and sustain force against hindering loads. We used both the three-bead assay, where force is oriented parallel to the microtubule, and the traditional single-bead assay, wher...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e034d443-e3d9-54b0-8709-f6ed81dfcceb
DOI: 10.1101/2022.05.16.492183

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

KIF1A is kinetically tuned to be a super-engaging motor under hindering loadsDOI 10.1101/2022.05.16.492183Read

KIF1A is kinetically tuned to be a superengaging motor under hindering loads.Semantic proximity Read

Pathogenic Mutations in the Kinesin-3 Motor KIF1A Diminish Force Generation and Movement Through Allosteric MechanismsSemantic proximity Read

Force generation of KIF1C is impaired by pathogenic mutationsSemantic proximity Read

Force generation of KIF1C is impaired by pathogenic mutations.Semantic proximity Read

Intracellular force comparison of pathogenic KIF1A, KIF5, and dynein by fluctuation analysisSemantic proximity Read

Spatial Relationships Matter: Kinesin-1 Molecular Motors Transport Liposome Cargo Through 3D Microtubule Intersections <i>In Vitro</i>Semantic proximity Read

Intrinsically disordered domain of kinesin-3 Kif14 enables unique functional diversitySemantic proximity Read

Tau directs intracellular trafficking by regulating the forces exerted by kinesin and dynein teamsSemantic proximity Read

Kinesin-1 motors can circumvent permanent roadblocks by side-shifting to neighboring protofilaments.Semantic proximity Read

Intellectual disability-causing mutations in KIF11 impair microtubule dynamics and dendritic arborization.Semantic proximity Read

Effects of the dynein inhibitor dynarrestin on the number of motor proteins transporting synaptic cargosSemantic proximity Read

Tug-of-war as a cooperative mechanism for bidirectional cargo transport by molecular motors.Semantic proximity Read