Article
R-loop-derived cytoplasmic RNA-DNA hybrids activate an immune response.
Nature - 1 Jan 2023
Crossley Magdalena P, Song Chenlin, Bocek Michael J, Choi Jun-Hyuk, Kousouros Joseph N, Sathirachinda Ataya, Lin Cindy, Brickner Joshua R, Bai Gongshi, Lans Hannes, Vermeulen Wim, Abu-Remaileh Monther, Cimprich Karlene A
Abstract excerpt
R-loops are RNA-DNA-hybrid-containing nucleic acids with important cellular roles. Deregulation of R-loop dynamics can lead to DNA damage and genome instability1, which has been linked to the action of endonucleases such as XPG2-4. However, the mechanisms and cellular consequences of such processing have remained unclear. Here we identify a new population of RNA-DNA hybrids in the cytoplasm that are...
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