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Article

Out of balance: R-loops in human disease.

PLoS genetics - 1 Sept 2014

Groh Matthias, Gromak Natalia

Abstract excerpt

R-loops are cellular structures composed of an RNA/DNA hybrid, which is formed when the RNA hybridises to a complementary DNA strand and a displaced single-stranded DNA. R-loops have been detected in various organisms from bacteria to mammals and play crucial roles in regulating gene expression, DNA and histone modifications, immunoglobulin class switch recombination, DNA replication, and genome stability. Recent...

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Identifiers

PMID: 25233079
DOI: 10.1371/journal.pgen.1004630
PMCID: PMC4169248

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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