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Article

R-loops in neurodegeneration

8 Apr 2025

Abstract excerpt

Neurodegenerative diseases are associated with the progressive loss of neurons. R-loops are non-canonical nucleic acid structures formed during transcription and composed of an RNA/DNA hybrid and a displaced single-stranded DNA. Whilst R-loops are important regulators of cellular processes, they are also associated with the pathologies of multiple disorders, including repeat expansion, motor neuron, inflammatory...

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PMID: 40203732
DOI: 10.1016/j.gde.2025.102345

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