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Article

Mendelian randomization of genetically independent aging phenotypes identifies LPA and VCAM1 as biological targets for human aging.

Nature aging - 1 Jan 2022

Timmers Paul R H J, Tiys Evgeny S, Sakaue Saori, Akiyama Masato, Kiiskinen Tuomo T J, Zhou Wei, Hwang Shih-Jen, Yao Chen, Deelen Joris, Levy Daniel, Ganna Andrea, Kamatani Yoichiro, Okada Yukinori, Joshi Peter K, Wilson James F, Tsepilov Yakov A

Abstract excerpt

Length and quality of life are important to us all, yet identification of promising drug targets for human aging using genetics has had limited success. In the present study, we combine six European-ancestry genome-wide association studies of human aging traits-healthspan, father and mother lifespan, exceptional longevity, frailty index and self-rated health-in a principal component framework that maximizes their...

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PMID: 37118362
DOI: 10.1038/s43587-021-00159-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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