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Article

Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging.

Nature aging - 1 Aug 2023

Rosoff Daniel B, Mavromatis Lucas A, Bell Andrew S, Wagner Josephin, Jung Jeesun, Marioni Riccardo E, Davey Smith George, Horvath Steve, Lohoff Falk W

Abstract excerpt

The concept of aging is complex, including many related phenotypes such as healthspan, lifespan, extreme longevity, frailty and epigenetic aging, suggesting shared biological underpinnings; however, aging-related endpoints have been primarily assessed individually. Using data from these traits and multivariate genome-wide association study methods, we modeled their underlying genetic factor ('mvAge'). mvAge...

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PMID: 37550455
DOI: 10.1038/s43587-023-00455-5
PMCID: PMC10432278

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