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Article

Genetic links between multimorbidity and human aging.

GeroScience - 1 Oct 2026

Dinh Phuong-Anh, Han HyeRim, Kim Seungsoo, Guo Qinghua, Zhang Zhengdong D, Vijg Jan, Suh Yousin

Abstract excerpt

The growing epidemiological burden of multimorbidity among older adults underscores an urgent need to develop interventions that can address multiple age-related diseases (ARDs) at once. Yet, the biological mechanisms driving their co-occurrence remain poorly understood. In this study, we conducted a multivariate genome-wide association analysis to dissect the shared genetic architecture of five common ARDs:...

Read the complete abstract on PubMed

Topics

Humans
Multimorbidity
Aging
Genome-Wide Association Study
Aged
Female
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Diabetes Mellitus, Type 2

Genetic Predisposition to Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 41405793
DOI: 10.1007/s11357-025-02044-3
PMCID: PMC13601487

Genes

DCAF16
GTF2B
MGA
PHF13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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