Article

Low Genetic Risk for Coronary Artery Disease underlies Multigenerational Longevity and Healthy Aging

2025-12-04

Abstract excerpt

Descendants of exceptionally long-lived families have a delayed onset of their first chronic disease. We therefore hypothesize that one of the key features explaining healthy survival up to high ages is the absence of chronic disease risk alleles. Using the LLS and Leiden85+ multigenerational cohorts and Polygenic Scores (PGS) for chronic diseases, we showed that an increasing number of long-lived ancestors is add...

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Literature Corpus work: 182011fe-463d-5d2f-ab65-80ee12221eb4
DOI: 10.64898/2025.12.03.25341464

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