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A trans-omic Mendelian randomization study of parental lifespan uncovers novel aging biology and therapeutic candidates for chronic diseases.

Aging cell - 1 Nov 2021

Perrot Nicolas, Pelletier William, Bourgault Jérôme, Couture Christian, Li Zhonglin, Mitchell Patricia L, Ghodsian Nooshin, Bossé Yohan, Thériault Sébastien, Mathieu Patrick, Arsenault Benoit J

Abstract excerpt

The study of parental lifespan has emerged as an innovative tool to advance aging biology and our understanding of the genetic architecture of human longevity and aging-associated diseases. Here, we leveraged summary statistics of a genome-wide association study including over one million parental lifespans to identify genetically regulated genes from the Genotype-Tissue Expression project. Through a combination...

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PMID: 34704651
DOI: 10.1111/acel.13497
PMCID: PMC8590095

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