Article

Genetically independent phenotype analysis identifies LPA and VCAM1 as drug targets for human ageing

2021-01-23

Abstract excerpt

The length and quality of life is important to us all, yet identification of promising drug targets for human ageing using genetics has had limited success. Here, we combine six large European-ancestry genome-wide association studies (GWAS) of human ageing traits—healthspan, father and mother lifespan, exceptional longevity, frailty index, and self-rated health—in a principal component framework that maximises the...

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Literature Corpus work: 9b3271de-3b0b-5455-9be3-8d3698179914
DOI: 10.1101/2021.01.22.427837

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