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Article

Beneficial effects of exercise initiated before development of hypertrophic cardiomyopathy in genotype-positive mice.

American journal of physiology. Heart and circulatory physiology - 1 Jun 2023

Andreassen Kristine, Rixon Chloe, Hansen Marie H, Hauge-Iversen Ida Marie, Zhang Lili, Sadredini Mani, Erusappan Pugazendhi M, Sjaastad Ivar, Christensen Geir, Haugaa Kristina H, Edvardsen Thor, Lunde Ida G, Stokke Mathis K

Abstract excerpt

The effect of exercise on disease development in hypertrophic cardiomyopathy (HCM) genotype-positive individuals is unresolved. Our objective was to test the effect of exercise training initiated before phenotype development on cardiac fibrosis, morphology, and function in a mouse model of HCM. Genotype-positive Myh6 R403Q mice exposed to cyclosporine A (CsA) for induction of HCM (HCM mice) were allocated to...

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Identifiers

PMID: 37115627
DOI: 10.1152/ajpheart.00701.2022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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