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Article

Progression from hypertrophic to dilated cardiomyopathy in mice that express a mutant myosin transgene.

American journal of physiology. Heart and circulatory physiology - 1 Jan 2001

Freeman K, Colon-Rivera C, Olsson M C, Moore R L, Weinberger H D, Grupp I L, Vikstrom K L, Iaccarino G, Koch W J, Leinwand L A

Abstract excerpt

A mouse model of hypertrophic cardiomyopathy (HCM) was created by expression of a cardiac alpha-myosin transgene including the R(403)Q mutation and a deletion of a segment of the actin-binding domain. HCM mice show early histopathology and hypertrophy, with progressive hypertrophy in females and ventricular dilation in older males. To test the hypothesis that dilated cardiomyopathy (DCM) is part of the...

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Identifiers

PMID: 11123229
DOI: 10.1152/ajpheart.2001.280.1.H151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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