Article
Comparison of two murine models of familial hypertrophic cardiomyopathy.
Circulation research - 2 Mar 2001
McConnell B K, Fatkin D, Semsarian C, Jones K A, Georgakopoulos D, Maguire C T, Healey M J, Mudd J O, Moskowitz I P, Conner D A, Giewat M, Wakimoto H, Berul C I, Schoen F J, Kass D A, Seidman C E, Seidman J G
Abstract excerpt
Although sarcomere protein gene mutations cause familial hypertrophic cardiomyopathy (FHC), individuals bearing a mutant cardiac myosin binding protein C (MyBP-C) gene usually have a better prognosis than individuals bearing beta-cardiac myosin heavy chain (MHC) gene mutations. Heterozygous mice bearing a cardiac MHC missense mutation (alphaMHC(403/+) or a cardiac MyBP-C mutation (MyBP-C(t/+)) were constructed as...
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