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Article

Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy.

The New England journal of medicine - 5 Aug 2010

Ho Carolyn Y, López Begoña, Coelho-Filho Otavio R, Lakdawala Neal K, Cirino Allison L, Jarolim Petr, Kwong Raymond, González Arantxa, Colan Steven D, Seidman J G, Díez Javier, Seidman Christine E

Abstract excerpt

BACKGROUND: Myocardial fibrosis is a hallmark of hypertrophic cardiomyopathy and a proposed substrate for arrhythmias and heart failure. In animal models, profibrotic genetic pathways are activated early, before hypertrophic remodeling. Data showing early profibrotic responses to sarcomere-gene mutations in patients with hypertrophic cardiomyopathy are lacking. METHODS: We used echocardiography, cardiac magnetic...

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Share to Cardiac Myosins
Share to Cardiomyopathy, Hypertrophic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Collagen Type I

Share to Echocardiography

Share to Fibrosis

Share to Hypertrophy, Left Ventricular

Share to Myosin Heavy Chains

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Source

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Identifiers

PMID: 20818890
DOI: 10.1056/NEJMoa1002659
PMCID: PMC3049917

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