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Article

Blocking cardiac growth in hypertrophic cardiomyopathy induces cardiac dysfunction and decreased survival only in males.

American journal of physiology. Heart and circulatory physiology - 1 Feb 2007

Luckey Stephen W, Mansoori Jason, Fair Kelly, Antos Christopher L, Olson Eric N, Leinwand Leslie A

Abstract excerpt

Mutations in myosin heavy chain (MyHC) can cause hypertrophic cardiomyopathy (HCM) that is characterized by hypertrophy, histopathology, contractile dysfunction, and sudden death. The signaling pathways involved in the pathology of HCM have not been elucidated, and an unresolved question is whether blocking hypertrophic growth in HCM may be maladaptive or beneficial. To address these questions, a mouse model of...

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Source

Identifiers

PMID: 17012357
DOI: 10.1152/ajpheart.00615.2006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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