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Article

Morphological and functional alterations in ventricular myocytes from male transgenic mice with hypertrophic cardiomyopathy.

Circulation research - 6 Feb 2004

Olsson M Charlotte, Palmer Bradley M, Stauffer Brian L, Leinwand Leslie A, Moore Russell L

Abstract excerpt

Familial hypertrophic cardiomyopathy (FHC) is a human genetic disorder caused by mutations in sarcomeric proteins. It is generally characterized by cardiac hypertrophy, fibrosis, and myocyte disarray. A transgenic mouse model of FHC with mutations in the actin-binding domain of the alpha-myosin heavy chain (MyHC) gene displays many phenotypes similar to human FHC. At 4 months, male transgenic (TG) mice present...

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Source

Identifiers

PMID: 14670849
DOI: 10.1161/01.RES.0000111521.40760.18

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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