Article
Familial hypertrophic cardiomyopathy mice display gender differences in electrophysiological abnormalities.
Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing - 1 Mar 1998
Berul C I, Christe M E, Aronovitz M J, Maguire C T, Seidman C E, Seidman J G, Mendelsohn M E
Abstract excerpt
Genetically-manipulated mice harboring an alpha-myosin heavy chain Arg403Gln missense mutation (alpha-MHC403/+) display a phenotype characteristic of familial hypertrophic cardiomyopathy (FHC). Male and female (30 +/- 8 week old) heterozygous alpha-MHC403/+ mice and litter-mate controls were eval...
Topics
- Animals
- Arginine
- Cardiac Pacing, Artificial
- Cardiomyopathy, Hypertrophic
- Case-Control Studies
- Electrocardiography
- Female
- Glutamine
- Heart Conduction System
- Heart Rate
- Heart Ventricles
- Heterozygote
- Male
- Mice
- Mice, Inbred Strains