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Article

Irreversible triggers for hypertrophic cardiomyopathy are established in the early postnatal period.

Journal of the American College of Cardiology - 17 Feb 2015

Cannon Leah, Yu Ze-Yan, Marciniec Tadeusz, Waardenberg Ashley J, Iismaa Siiri E, Nikolova-Krstevski Vesna, Neist Elysia, Ohanian Monique, Qiu Min Ru, Rainer Stephen, Harvey Richard P, Feneley Michael P, Graham Robert M, Fatkin Diane

Abstract excerpt

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere protein genes, and left ventricular hypertrophy (LVH) develops as an adaptive response to sarcomere dysfunction. It remains unclear whether persistent expression of the mutant gene is required for LVH or whether early gene expression acts as an immutable inductive trigger. OBJECTIVES: The aim of this study was to use a regulatable...

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PMID: 25677315
DOI: 10.1016/j.jacc.2014.10.069

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