Article
Comparative phenotypic assessment of cardiac pathology, physiology, and gene expression in C3H/HeJ, C57BL/6J, and B6C3F1/J mice.
Toxicologic pathology - 1 Oct 2010
Auerbach Scott S, Thomas Reuben, Shah Ruchir, Xu Hong, Vallant Molly K, Nyska Abraham, Dunnick June K
Abstract excerpt
Human cardiomyopathies often lead to heart failure, a major cause of morbidity and mortality in industrialized nations. Described here is a phenotypic characterization of cardiac function and genome-wide expression from C3H/HeJ, C57BL/6J, and B6C3F1/J male mice. Histopathologic analysis identified a low-grade background cardiomyopathy (murine progressive cardiomyopathy) in eight of nine male C3H/HeJ mice (age...
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