Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A mouse model of familial hypertrophic cardiomyopathy.

Science (New York, N.Y.) - 3 May 1996

Geisterfer-Lowrance A A, Christe M, Conner D A, Ingwall J S, Schoen F J, Seidman C E, Seidman J G

Abstract excerpt

A mouse model of familial hypertrophic cardiomyopathy (FHC) was generated by the introduction of an Arg 403 --> Gln mutation into the alpha cardiac myosin heavy chain (MHC) gene. Homozygous alpha MHC 403/403 mice died 7 days after birth, and sedentary heterozygous alpha MHC 403/+ mice survived for 1 year. Cardiac histopathology and dysfunction in the alpha MHC 403/+ mice resembled human FHC. Cardiac dysfunction...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Disease Models, Animal
Share to Heterozygote

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Homozygote

Share to Mice, Mutant Strains

Share to Molecular Sequence Data

Share to Mutation

Source

Identifiers

PMID: 8614836
DOI: 10.1126/science.272.5262.731

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A mouse model of familial hypertrophic cardiomyopathy.PMID 8614836Read ↗

Comparison of two murine models of familial hypertrophic cardiomyopathy.Semantic proximity Read ↗

Familial hypertrophic cardiomyopathy mice display gender differences in electrophysiological abnormalities.Semantic proximity Read ↗

Age-related changes in familial hypertrophic cardiomyopathy phenotype in transgenic mice and humans.Semantic proximity Read ↗

Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy.Semantic proximity Read ↗

A familial hypertrophic cardiomyopathy alpha-tropomyosin mutation causes severe cardiac hypertrophy and death in mice.Semantic proximity Read ↗

Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene.Semantic proximity Read ↗

Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backbone.Semantic proximity Read ↗

Mouse model of a familial hypertrophic cardiomyopathy mutation in alpha-tropomyosin manifests cardiac dysfunction.Semantic proximity Read ↗

Animal models of hypertrophic cardiomyopathy.Semantic proximity Read ↗

Progression from hypertrophic to dilated cardiomyopathy in mice that express a mutant myosin transgene.Semantic proximity Read ↗

Morphological and functional alterations in ventricular myocytes from male transgenic mice with hypertrophic cardiomyopathy.Semantic proximity Read ↗

A molecular basis for familial hypertrophic cardiomyopathy: a beta cardiac myosin heavy chain gene missense mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.