Article
A mouse model of familial hypertrophic cardiomyopathy.
Science (New York, N.Y.) - 3 May 1996
Geisterfer-Lowrance A A, Christe M, Conner D A, Ingwall J S, Schoen F J, Seidman C E, Seidman J G
Abstract excerpt
A mouse model of familial hypertrophic cardiomyopathy (FHC) was generated by the introduction of an Arg 403 --> Gln mutation into the alpha cardiac myosin heavy chain (MHC) gene. Homozygous alpha MHC 403/403 mice died 7 days after birth, and sedentary heterozygous alpha MHC 403/+ mice survived fo...
Topics
- Animals
- Base Sequence
- Cardiac Output
- Cardiomyopathy, Hypertrophic
- Disease Models, Animal
- Female
- Gene Transfer Techniques
- Heart
- Heterozygote
- Homozygote
- Humans
- Male
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data
- Mutation
- Myocardium
- Myosin Heavy Chains