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Article

Omicron Spike Protein is Vulnerable to Reduction.

Journal of molecular biology - 1 Jul 2023

Yao Zhong, Geng Betty, Marcon Edyta, Pu Shuye, Tang Hua, Merluza John, Bello Alexander, Snider Jamie, Lu Ping, Wood Heidi, Stagljar Igor

Abstract excerpt

SARS-CoV-2 virus spike (S) protein is an envelope protein responsible for binding to the ACE2 receptor, driving subsequent entry into host cells. The existence of multiple disulfide bonds in the S protein makes it potentially susceptible to reductive cleavage. Using a tri-part split luciferase-based binding assay, we evaluated the impacts of chemical reduction on S proteins from different virus variants and found...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Spike Glycoprotein, Coronavirus

Source

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Identifiers

PMID: 37100168
DOI: 10.1016/j.jmb.2023.168128
PMCID: PMC10125213

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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