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Article

Highly Sensitive Detection Method of CXCR4 Tumor Hotspot Mutations by Drop-Off Droplet Digital PCR in Patients with IgM Monoclonal Gammopathies.

The Journal of molecular diagnostics : JMD - 1 Jul 2023

Markou Athina N, Bagratuni Tina, Tsakiri Christina, Tserpeli Victoria, Skourti Stamatia, Mavrianou Koutsoukou Nefeli, Papadimou Alexandra, Terpos Evangelos, Kastritis Efstathios, Lianidou Evi, Dimopoulos Meletios-Athanasios

Abstract excerpt

CXCR4 mutations impact disease presentation and treatment outcomes in Waldenström macroglobulinemia. Current techniques used for CXCR4 mutation detection have a number of limitations. The aim of the present study was to develop and analytically validate a novel droplet digital PCR (ddPCR) assay for the simultaneous detection of five of the most common CXCR4 mutations in bone marrow (BM). In silico novel primers...

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Identifiers

PMID: 37088135
DOI: 10.1016/j.jmoldx.2023.03.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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