Prognostic impact of MYD88 and CXCR4 mutations assessed by droplet digital polymerase chain reaction in IgM monoclonal gammopathy of undetermined significance and smouldering Waldenström macroglobulinaemia.

doi:10.1111/bjh.18502

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Prognostic impact of MYD88 and CXCR4 mutations assessed by droplet digital polymerase chain reaction in IgM monoclonal gammopathy of undetermined significance and smouldering Waldenström macroglobulinaemia.

British journal of haematology - 1 Jan 2023

Moreno David F, López-Guerra Mónica, Paz Sara, Oliver-Caldés Aina, Mena Mari-Pau, Correa Juan G, Battram Anthony M, Osuna Miguel, Rivas-Delgado Alfredo, Rodríguez-Lobato Luis Gerardo, Cardús Oriol, Tovar Natalia, Cibeira María Teresa, Jiménez-Segura Raquel, Bladé Joan, Rosiñol Laura, Colomer Dolors, Fernández de Larrea Carlos

Abstract excerpt

Waldenström macroglobulinaemia (WM) is characterized by recurrent somatic mutations in MYD88 and CXCR4 genes. However, limitations arise when analysing these mutations in IgM monoclonal gammopathy of undetermined significance (MGUS) or smouldering WM (SWM) given the lower tumour load. Here, we used droplet digital polymerase chain reaction (ddPCR) to analyse MYD88 L265P and CXCR4 S338* mutations (C1013G and...

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PMID: 36210485
DOI: 10.1111/bjh.18502
PMCID: PMC10092069

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