Highly sensitive MYD88L265P mutation detection by droplet digital polymerase chain reaction in Waldenström macroglobulinemia.

doi:10.3324/haematol.2017.186528

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Article

Highly sensitive MYD88L265P mutation detection by droplet digital polymerase chain reaction in Waldenström macroglobulinemia.

Haematologica - 1 Jun 2018

Drandi Daniela, Genuardi Elisa, Dogliotti Irene, Ferrante Martina, Jiménez Cristina, Guerrini Francesca, Schirico Mariella Lo, Mantoan Barbara, Muccio Vittorio, Lia Giuseppe, Zaccaria Gian Maria, Omedè Paola, Passera Roberto, Orsucci Lorella, Benevolo Giulia, Cavallo Federica, Galimberti Sara, Sanz Ramón García, Boccadoro Mario, Ladetto Marco, Ferrero Simone

Abstract excerpt

We here describe a novel method for MYD88L265P mutation detection and minimal residual disease monitoring in Waldenström macroglobulinemia, by droplet digital polymerase chain reaction, in bone marrow and peripheral blood cells, as well as in circulating cell-free DNA. Our method shows a sensitivity of 5.00×10-5, which is far superior to the widely used allele-specific polymerase chain reaction (1.00×10-3)....

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PMID: 29567768
DOI: 10.3324/haematol.2017.186528
PMCID: PMC6058774

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