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MYD88L265P Detection in IgM Monoclonal Gammopathies: Methodological Considerations for Routine Implementation

26 Apr 2021

Abstract excerpt

In IgM monoclonal gammopathies MYD88L265P is a prognostic and predictive biomarker of therapy response. MYD88L265P detection is mainly performed by allele-specific quantitative PCR (ASqPCR), however recently, droplet digital PCR (ddPCR) has been proved to be suitable for MYD88L265P screening and minimal residual disease monitoring (MRD). This study compared ASqPCR and ddPCR to define the most sensitive method for...

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PMID: 33926007
DOI: 10.3390/diagnostics11050779

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