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Digital Droplet PCR in Hematologic Malignancies: A New Useful Molecular Tool

24 May 2022

Abstract excerpt

Digital droplet PCR (ddPCR) is a recent version of quantitative PCR (QT-PCR), useful for measuring gene expression, doing clonality assays and detecting hot spot mutations. In respect of QT-PCR, ddPCR is more sensitive, does not need any reference curve and can quantify one quarter of samples already defined as “positive but not quantifiable”. In the IgH and TCR clonality assessment, ddPCR recapitulates the...

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PMID: 35741115
DOI: 10.3390/diagnostics12061305

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