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Article

A Novel Test for Detecting SNP-SNP Interactions in Case-Only Trio Studies.

Genetics - 1 Apr 2016

Balliu Brunilda, Zaitlen Noah

Abstract excerpt

Epistasis plays a significant role in the genetic architecture of many complex phenotypes in model organisms. To date, there have been very few interactions replicated in human studies due in part to the multiple-hypothesis burden implicit in genome-wide tests of epistasis. Therefore, it is of paramount importance to develop the most powerful tests possible for detecting interactions. In this work we develop a...

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Algorithms
Epistasis, Genetic
Genetic Testing
Genetics, Population
Genome-Wide Association Study
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Genetic

Polymorphism, Single Nucleotide

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Identifiers

PMID: 26865367
DOI: 10.1534/genetics.115.179846
PMCID: PMC4905548

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