Article
Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis.
Nature - 1 Apr 2023
Weinstock Joshua S, Gopakumar Jayakrishnan, Burugula Bala Bharathi, Uddin Md Mesbah, Jahn Nikolaus, Belk Julia A, Bouzid Hind, Daniel Bence, Miao Zhuang, Ly Nghi, Mack Taralynn M, Luna Sofia E, Prothro Katherine P, Mitchell Shaneice R, Laurie Cecelia A, Broome Jai G, Taylor Kent D, Guo Xiuqing, Sinner Moritz F, von Falkenhausen Aenne S, Kääb Stefan, Shuldiner Alan R, O'Connell Jeffrey R, Lewis Joshua P, Boerwinkle Eric, Barnes Kathleen C, Chami Nathalie, Kenny Eimear E, Loos Ruth J F, Fornage Myriam, Hou Lifang, Lloyd-Jones Donald M, Redline Susan, Cade Brian E, Psaty Bruce M, Bis Joshua C, Brody Jennifer A, Silverman Edwin K, Yun Jeong H, Qiao Dandi, Palmer Nicholette D, Freedman Barry I, Bowden Donald W, Cho Michael H, DeMeo Dawn L, Vasan Ramachandran S, Yanek Lisa R, Becker Lewis C, Kardia Sharon L R, Peyser Patricia A, He Jiang, Rienstra Michiel, Van der Harst Pim, Kaplan Robert, Heckbert Susan R, Smith Nicholas L, Wiggins Kerri L, Arnett Donna K, Irvin Marguerite R, Tiwari Hemant, Cutler Michael J, Knight Stacey, Muhlestein J Brent, Correa Adolfo, Raffield Laura M, Gao Yan, de Andrade Mariza, Rotter Jerome I, Rich Stephen S, Tracy Russell P, Konkle Barbara A, Johnsen Jill M, Wheeler Marsha M, Smith J Gustav, Melander Olle, Nilsson Peter M, Custer Brian S, Duggirala Ravindranath, Curran Joanne E, Blangero John, McGarvey Stephen, Williams L Keoki, Xiao Shujie, Yang Mao, Gu C Charles, Chen Yii-Der Ida, Lee Wen-Jane, Marcus Gregory M, Kane John P, Pullinger Clive R, Shoemaker M Benjamin, Darbar Dawood, Roden Dan M, Albert Christine, Kooperberg Charles, Zhou Ying, Manson JoAnn E, Desai Pinkal, Johnson Andrew D, Mathias Rasika A, Blackwell Thomas W, Abecasis Goncalo R, Smith Albert V, Kang Hyun M, Satpathy Ansuman T, Natarajan Pradeep, Kitzman Jacob O, Whitsel Eric A, Reiner Alexander P, Bick Alexander G, Jaiswal Siddhartha
Abstract excerpt
Mutations in a diverse set of driver genes increase the fitness of haematopoietic stem cells (HSCs), leading to clonal haematopoiesis1. These lesions are precursors for blood cancers2-6, but the basis of their fitness advantage remains largely unknown, partly owing to a paucity of large cohorts in which the clonal expansion rate has been assessed by longitudinal sampling. Here, to circumvent this limitation, we...
