Article

Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis

2021-09-15

Abstract excerpt

DNA Methyltransferase 3A (DNMT3A) is an important facilitator of differentiation of both embryonic and hematopoietic stem cells. Heterozygous germline mutations in DNMT3A lead to Tatton-Brown-Rahman Syndrome (TBRS), characterized by obesity and excessive height. While DNMT3A is known to impact feeding behavior via the hypothalamus, here we investigated a role in adipocyte progenitors utilizing heterozygous knocko...

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Literature Corpus work: 6d6f7489-b519-5876-be38-79d956318797
DOI: 10.1101/2021.09.13.460063

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