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Aging and Obesity Prime the Methylome and Transcriptome of Adipose Stem Cells for Disease and Dysfunction

2022-09-26

Abstract excerpt

The epigenome of stem cells occupies a critical interface between genes and environment, serving to regulate expression through modification by intrinsic and extrinsic factors. We hypothesized that aging and obesity, which represent major risk factors for a variety of diseases, synergistically modify the epigenome of adult adipose stem cells (ASCs). Using integrated RNA- and targeted bisulfite-sequencing in murine...

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Literature Corpus work
932ecda9-16fc-5aba-88a2-54ca75dbe554
DOI
10.1101/2022.09.26.509507
Open publication

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Aging and Obesity Prime the Methylome and Transcriptome of Adipose Stem Cells for Disease and DysfunctionDOI 10.1101/2022.09.26.509507
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