Article

Systemic deficits in lipid homeostasis promote aging-associated impairments in B cell progenitor development

2024-09-26

Abstract excerpt

<h4>ABSTRACT</h4> Organismal aging has been associated with diverse metabolic and functional changes across tissues. Within the immune system, key features of physiological hematopoietic cell aging include increased fat deposition in the bone marrow, impaired hematopoietic stem and progenitor cell (HSPC) function, and a propensity towards myeloid differentiation. This shift in lineage bias can lead to pre-maligna...

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Literature Corpus work: a3afa4c7-57e3-53e4-bc2d-4bd666c451fa
DOI: 10.1101/2024.09.26.614999

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