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Article

A fitness trade-off explains the early fate of yeast aneuploids with chromosome gains.

Proceedings of the National Academy of Sciences of the United States of America - 11 Apr 2023

Pompei Simone, Cosentino Lagomarsino Marco

Abstract excerpt

The early development of aneuploidy from an accidental chromosome missegregation shows contrasting effects. On the one hand, it is associated with significant cellular stress and decreased fitness. On the other hand, it often carries a beneficial effect and provides a quick (but typically transient) solution to external stress. These apparently controversial trends emerge in several experimental contexts,...

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Identifiers

PMID: 37018197
DOI: 10.1073/pnas.2211687120
PMCID: PMC10104565

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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