Article
Whole chromosome aneuploidy: big mutations drive adaptation by phenotypic leap.
BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Oct 2012
Chen Guangbo, Rubinstein Boris, Li Rong
Abstract excerpt
Despite its widespread existence, the adaptive role of aneuploidy (the abnormal state of having an unequal number of different chromosomes) has been a subject of debate. Cellular aneuploidy has been associated with enhanced resistance to stress, whereas on the organismal level it is detrimental to multicellular species. Certain aneuploid karyotypes are deleterious for specific environments, but karyotype...
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