Article

The response to single-gene duplication implicates translation as a key vulnerability in aneuploid yeast

2024-04-20

Abstract excerpt

<h4>ABSTRACT</h4> Aneuploidy produces myriad consequences in health and disease, yet models of the deleterious effects of chromosome amplification are still widely debated. To distinguish the molecular determinants of aneuploidy stress, we measured the effects of duplicating individual genes in cells with varying chromosome duplications, in wild-type cells and cells sensitized to aneuploidy by deletion of RNA-bin...

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Literature Corpus work: aed85669-4c77-59a6-bdd0-058634df6861
DOI: 10.1101/2024.04.15.589582

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