Article
Molecular signatures of aneuploidy-driven adaptive evolution.
Nature communications - 30 Jan 2020
Kaya Alaattin, Mariotti Marco, Tyshkovskiy Alexander, Zhou Xuming, Hulke Michelle L, Ma Siming, Gerashchenko Maxim V, Koren Amnon, Gladyshev Vadim N
Abstract excerpt
Alteration of normal ploidy (aneuploidy) can have a number of opposing effects, such as unbalancing protein abundances and inhibiting cell growth but also accelerating genetic diversification and rapid adaptation. The interplay of these detrimental and beneficial effects remains puzzling. Here, to understand how cells develop tolerance to aneuploidy, we subject disomic (i.e. with an extra chromosome copy) strains...
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