Article
Chromosomal duplication is a transient evolutionary solution to stress.
Proceedings of the National Academy of Sciences of the United States of America - 18 Dec 2012
Yona Avihu H, Manor Yair S, Herbst Rebecca H, Romano Gal H, Mitchell Amir, Kupiec Martin, Pilpel Yitzhak, Dahan Orna
Abstract excerpt
Aneuploidy, an abnormal number of chromosomes, is a widespread phenomenon found in unicellulars such as yeast, as well as in plants and in mammalians, especially in cancer. Aneuploidy is a genome-scale aberration that imposes a severe burden on the cell, yet under stressful conditions specific aneuploidies confer a selective advantage. This dual nature of aneuploidy raises the question of whether it can serve as...
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