Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aneuploid proliferation defects in yeast are not driven by copy number changes of a few dosage-sensitive genes.

Genes & development - 1 May 2015

Bonney Megan E, Moriya Hisao, Amon Angelika

Abstract excerpt

Aneuploidy-the gain or loss of one or more whole chromosome-typically has an adverse impact on organismal fitness, manifest in conditions such as Down syndrome. A central question is whether aneuploid phenotypes are the consequence of copy number changes of a few especially harmful genes that may...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aneuploidy
Share to Cell Proliferation
Share to Chromosomes, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Copy Number Variations

Share to Gene Dosage

Share to Phenotype

Share to Saccharomyces cerevisiae

Source

Open in PubMed Open full text

Identifiers

PMID: 25934502
DOI: 10.1101/gad.261743.115
PMCID: PMC4421978

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25934502-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aneuploid proliferation defects in yeast are not driven by copy number changes of a few dosage-sensitive genes.PMID 25934502Read ↗

Comparative modeling reveals the molecular determinants of aneuploidy fitness cost in a wild yeast modelSemantic proximity Read ↗

No evidence for whole-chromosome dosage compensation or global transcriptomic expression differences in spontaneously-aneuploid mutation accumulation lines of <i>Saccharomyces cerevisiae</i>Semantic proximity Read ↗

Aneuploidy Causes Non-genetic Individuality.Semantic proximity Read ↗

Whole chromosome aneuploidy: big mutations drive adaptation by phenotypic leap.Semantic proximity Read ↗

Molecular signatures of aneuploidy-driven adaptive evolution.Semantic proximity Read ↗

Combinatorial effects of multiple genes contribute to beneficial aneuploidy phenotypes.Semantic proximity Read ↗

Dosage compensation can buffer copy-number variation in wild yeast.Semantic proximity Read ↗

Phenotypic consequences of aneuploidy in Arabidopsis thaliana.Semantic proximity Read ↗

Never in neutral: a systems biology and evolutionary perspective on how aneuploidy contributes to human diseases.Semantic proximity Read ↗

Genetic variation in aneuploidy prevalence and tolerance across the <i>Saccharomyces cerevisiae</i> phylogenySemantic proximity Read ↗

The response to single-gene duplication implicates translation as a key vulnerability in aneuploid yeastSemantic proximity Read ↗

Aneuploidy underlies a multicellular phenotypic switch.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.