Altered access to beneficial mutations slows adaptation and biases fixed mutations in diploids.

Abstract excerpt

Ploidy varies considerably in nature. However, our understanding of the impact of ploidy on adaptation is incomplete. Many microbial evolution experiments characterize adaptation in haploid organisms, but few focus on diploid organisms. Here, we perform a 4,000-generation evolution experiment using diploid strains of the yeast Saccharomyces cerevisiae. We show that the rate of adaptation and spectrum of...

Topics

• Adaptation, Biological
• Diploidy
• Mutation
• Saccharomyces cerevisiae