Article

Comparative modeling reveals the molecular determinants of aneuploidy fitness cost in a wild yeast model

2024-04-13

Abstract excerpt

Although implicated as deleterious in many organisms, aneuploidy can underlie rapid phenotypic evolution. However, aneuploidy will only be maintained if the benefit outweighs the cost, which remains incompletely understood. To quantify this cost and the molecular determinants behind it, we generated a panel of chromosome duplications in Saccharomyces cerevisiae and applied comparative modeling and molecular valid...

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Identifiers and source

Literature Corpus work: 3bf1948f-cfb6-52ab-baed-294e5997804e
DOI: 10.1101/2024.04.09.588778

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