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Identifying regulators of aberrant stem cell and differentiation activity in colorectal cancer using a dual endogenous reporter system

12 Mar 2024

Abstract excerpt

Aberrant stem cell-like activity and impaired differentiation are central to the development of colorectal cancer (CRC). To identify functional mediators of these key cellular programs, we engineer a dual endogenous reporter system by genome-editing the SOX9 and KRT20 loci of human CRC cell lines to express fluorescent reporters, broadcasting aberrant stem cell-like and differentiation activity, respectively. By...

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PMID: 38472198
DOI: 10.1038/s41467-024-46285-w

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