Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic and transcriptomic impact of expressing mammalian TET2 in the Drosophila melanogaster model.

Epigenetics - 1 Dec 2023

Ismail Joy N, Mantash Sarah, Hallal Mohammad, Jabado Nada, Khoueiry Pierre, Shirinian Margret

Abstract excerpt

Ten-Eleven Translocation (TET) proteins have recently come to light as important epigenetic regulators conserved in multicellular organisms. TET knockdown studies in rodents have highlighted the critical role of these proteins for proper brain development and function. Mutations in mammalian mTET proteins and mTET2 specifically are frequent and deregulated in leukaemia and glioma respectively. Accordingly, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Circadian Rhythm
Share to Dioxygenases
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila melanogaster

Share to Drosophila Proteins

Share to Gene Expression Profiling

Share to Mammals

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 36989121
DOI: 10.1080/15592294.2023.2192375
PMCID: PMC10072067

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic and transcriptomic impact of expressing mammalian TET2 in the Drosophila melanogaster model.PMID 36989121Read ↗

Comparative analysis of Tet2 catalytic-deficient and knockout bone marrow over time.Semantic proximity Read ↗

Significance of TET2 mutations in myeloid and lymphoid neoplasms.Semantic proximity Read ↗

Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in MiceSemantic proximity Read ↗

Landscape of TET2 Mutations: From Hematological Malignancies to Solid TumorsSemantic proximity Read ↗

Role of TET dioxygenases in the regulation of both normal and pathological hematopoiesis.Semantic proximity Read ↗

TET2 in Normal and Malignant Hematopoiesis.Semantic proximity Read ↗

TET2: A cornerstone in normal and malignant hematopoiesis.Semantic proximity Read ↗

TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis.Semantic proximity Read ↗

TET2 mutation as prototypic clonal hematopoiesis lesion.Semantic proximity Read ↗

Dysregulation of TET2 in hematologic malignancies.Semantic proximity Read ↗

TET2 as an epigenetic master regulator for normal and malignant hematopoiesis.Semantic proximity Read ↗

Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.