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Article

TET2 in Normal and Malignant Hematopoiesis.

Cold Spring Harbor perspectives in medicine - 1 Aug 2017

Bowman Robert L, Levine Ross L

Abstract excerpt

The ten-eleven translocation (TET) family of enzymes were originally cloned from the translocation breakpoint of t(10;11) in infant acute myeloid leukemia (AML) with subsequent genomic analyses revealing somatic mutations and suppressed expression of TET family members across a range of malignancies, particularly enriched in hematological neoplasms. The TET family of enzymes is responsible for the hydroxylation...

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Share to 5-Methylcytosine
Share to Dioxygenases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Hematologic Neoplasms

Share to Hematopoiesis

Share to Oxidation-Reduction

Share to Proto-Oncogene Proteins

Source

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Identifiers

PMID: 28242787
DOI: 10.1101/cshperspect.a026518
PMCID: PMC5538403

Genes

TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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