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Article

Dysregulation of TET2 in hematologic malignancies.

International journal of hematology - 1 Jan 2017

Chiba Shigeru

Abstract excerpt

The TET dioxygenases, TET1, TET2, and TET3, catalyze transfer of an oxygen atom to the methyl group of 5-methylcytocine (5-mC), converting it to 5-hydroxymethylcytocine (5-hmC). Among the genes encoding these enzymes, ten-eleven translocation 2 (TET2) is frequently mutated somatically in both myeloid and lymphoid malignancies. Because these TET2 mutations result in the impairment of the dioxygenase activity of...

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Topics

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Share to Carcinogenesis
Share to Dioxygenases
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Gene Expression Regulation, Neoplastic

Share to Hematologic Neoplasms

Share to Proto-Oncogene Proteins

Share to Translocation, Genetic

Source

Identifiers

PMID: 27848178
DOI: 10.1007/s12185-016-2122-z

Genes

TET2
TET1
TET3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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