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Article

TET2 as an epigenetic master regulator for normal and malignant hematopoiesis.

Cancer science - 1 Sept 2014

Nakajima Hideaki, Kunimoto Hiroyoshi

Abstract excerpt

DNA methylation is one of the critical epigenetic modifications regulating various cellular processes such as differentiation or proliferation, and its dysregulation leads to disordered stem cell function or cellular transformation. The ten-eleven translocation (TET) gene family, initially found as a chromosomal translocation partner in leukemia, turned out to be a key enzyme for DNA demethylation. TET genes...

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Topics

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Share to Dioxygenases
Share to DNA-Binding Proteins
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Gene Expression Regulation, Neoplastic

Share to Hematologic Neoplasms

Share to Hematopoiesis

Share to Proto-Oncogene Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 25040794
DOI: 10.1111/cas.12484
PMCID: PMC4462392

Genes

TET2
IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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