Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of memantine on mania-like phenotypes exhibited by Drosophila Shaker mutants.

CNS neuroscience & therapeutics - 1 Jul 2023

Mocci Ignazia, Casu Maria Antonietta, Sogos Valeria, Liscia Anna, Angius Rossella, Cadeddu Francesca, Fanti Maura, Muroni Patrizia, Talani Giuseppe, Diana Andrea, Collu Maria, Setzu Maria Dolores

Abstract excerpt

INTRODUCTION: Increased glutamate levels and electrolytic fluctuations have been observed in acutely manic patients. Despite some efficacy of the non-competitive NMDA receptor antagonist memantine (Mem), such as antidepressant-like and mood-stabilizer drugs in clinical studies, its specific mechanisms of action are still uncertain. The present study aims to better characterize the Drosophila melanogaster fly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila
Share to Drosophila melanogaster

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutamic Acid

Share to Phenotype

Share to Receptors, N-Methyl-D-Aspartate

Source

Open in PubMed Open full text

Identifiers

PMID: 36942502
DOI: 10.1111/cns.14145
PMCID: PMC10324369

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of memantine on mania-like phenotypes exhibited by Drosophila Shaker mutants.PMID 36942502Read ↗

Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers.Semantic proximity Read ↗

A novel murine model of maniaSemantic proximity Read ↗

Restoring brain wiring, mobility, sleep, and lifespan with a novel repurposed modulator of voltage-gated K+ channels: an emerging perspective for channelopathies.Semantic proximity Read ↗

Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model.Semantic proximity Read ↗

Studies in humans and mice implicate neurocan in the etiology of mania.Semantic proximity Read ↗

NR1 knockdown mice as a representative model of the glutamate hypothesis of schizophrenia.Semantic proximity Read ↗

Does gene deletion of AMPA GluA1 phenocopy features of schizoaffective disorder?Semantic proximity Read ↗

Blocking Metabotropic Glutamate Receptor Subtype 7 via the Venus Flytrap Domain Promotes a Chronic Stress-Resilient Phenotype in Mice.Semantic proximity Read ↗

Age-dependent changes in memory and mushroom bodies in the Drosophila mutant vermilion deficient in the kynurenine pathway of tryptophan metabolism.Semantic proximity Read ↗

Lithium-Responsive Seizure-Like Hyperexcitability Is Caused by a Mutation in the Drosophila Voltage-Gated Sodium Channel Gene paralytic.Semantic proximity Read ↗

Antagonism of GluK1-containing Kainate Receptors Reduces Ethanol Consumption by Modulating Ethanol Reward and WithdrawalSemantic proximity Read ↗

The NMDA Receptor Promotes Sleep in the Fruit Fly, Drosophila melanogaster.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.