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Article

Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers.

JCI insight - 19 Oct 2017

Pappas Andrea L, Bey Alexandra L, Wang Xiaoming, Rossi Mark, Kim Yong Ho, Yan Haidun, Porkka Fiona, Duffney Lara J, Phillips Samantha M, Cao Xinyu, Ding Jin-Dong, Rodriguiz Ramona M, Yin Henry H, Weinberg Richard J, Ji Ru-Rong, Wetsel William C, Jiang Yong-Hui

Abstract excerpt

Genetic defects in the synaptic scaffolding protein gene, SHANK2, are linked to a variety of neuropsychiatric disorders, including autism spectrum disorders, schizophrenia, intellectual disability, and bipolar disorder, but the molecular mechanisms underlying the pleotropic effects of SHANK2 mutations are poorly understood. We generated and characterized a line of Shank2 mutant mice by deleting exon 24 (Δe24)....

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Identifiers

PMID: 29046483
DOI: 10.1172/jci.insight.92052
PMCID: PMC5846902

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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